ATG4D
Name
autophagy related 4D, cysteine peptidase
Synonyms
APG4-D, APG4D, AUTL4 [provided by Ensembl, GRCh37]
Location
chr19:10,654,571-10,664,094 (forward strand)
Summary
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Ensembl gene ID
Biotype
Protein coding
NCBI gene ID
Search for articles
Gene Networks
Gene regulatory network (GRN) of the gene in two interaction steps distance for the selected cell types. The network depth can be varied by updating the number in the box of Network Settings. The GRN is based on C3NET algorithm [1]. Each links are the highest association scores for one of the genes of gene pairs. The numbers near the checked boxes refer to the numbers of links contributed by each of the cell types. One can uncheck and remove the links of any of the cell types from the network. The network topology is dynamic and can be re-arranged by pulling a node with a mouse. The solid and dashed lines refer to positive and negative correlations, respectively. Right clicking a node will bring up a menu with additional options. The arrows show the most likely direction of regulation between gene pairs.
[1]
[2]
Gene regulatory network (GRN) of the gene in two interaction steps distance for the selected cell types. The network depth can be varied by updating the number in the box of Network Settings. The GRN is based on C3NET algorithm [1]. Each links are the highest association scores for one of the genes of gene pairs. The numbers near the checked boxes refer to the numbers of links contributed by each of the cell types. One can uncheck and remove the links of any of the cell types from the network. The network topology is dynamic and can be re-arranged by pulling a node with a mouse. The solid and dashed lines refer to positive and negative correlations, respectively. Right clicking a node will bring up a menu with additional options. The arrows show the most likely direction of regulation between gene pairs.
[1] [2]
| Source | Gene | Ensembl ID | Biotype | Corr. Sign | Corr. Magnitude (r) |
|---|
