AKR1B1


Name

aldo-keto reductase family 1, member B1 (aldose reductase)

Synonyms

ALDR1, ADR, AR, ALR2 [provided by Ensembl, GRCh37]

Location

chr7:134,127,102-134,144,036 (reverse strand)

Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]

Ensembl gene ID

ENSG00000085662

Biotype

Protein coding

NCBI gene ID

231

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Gene Networks

Gene regulatory network (GRN) of the gene in two interaction steps distance for the selected cell types. The network depth can be varied by updating the number in the box of Network Settings. The GRN is based on C3NET algorithm [1]. Each links are the highest association scores for one of the genes of gene pairs. The numbers near the checked boxes refer to the numbers of links contributed by each of the cell types. One can uncheck and remove the links of any of the cell types from the network. The network topology is dynamic and can be re-arranged by pulling a node with a mouse. The solid and dashed lines refer to positive and negative correlations, respectively. Right clicking a node will bring up a menu with additional options. The arrows show the most likely direction of regulation between gene pairs.


[1] [2]





Source Gene Ensembl ID Biotype Corr. Sign Corr. Magnitude (r)