integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)


GPIIb, GT, BDPLT16, HPA3, CD41, GTA, BDPLT2, GP2B, CD41B, ITGAB [provided by Ensembl, GRCh37]


chr17:42,449,548-42,466,873 (reverse strand)


This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016]


Protein coding

Ensembl gene ID


NCBI gene ID


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Gene expression

Expression levels for the gene of interest in transcripts per million (TPM, x-axis) within the cohort of donors studied. Cell types (y-axis) are sorted based on the median expression level within the cohort from highest to lowest. Boxes indicate 25%-75% interquartile ranges, and whiskers indicate minimum to maximum.

Differential expression

Differential gene expression across cell types as calculated by the DESeq package (version 1.6.3). Cells are sorted based on median gene expression from highest to lowest. Squares in the upper diagonal matrix indicate results from pair-wise comparisons of two cell types on the x- and y-axis. Changing the tab on top will switch from log2 fold change to P values, and mousing over the squares will display those values. Adjusting the threshold slider will change the color of the square to indicate if it is above or below the threshold.

P value threshold

Log2 fold change threshold

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Discovery of genetic variants directly associated with the gene expression level (SNP located within +/- 1 Mb of the TSS); 'expression quantitative trait loci' (eQTL). Hover over the table headers for a description of several of the fields.

SNP ID Cell type Position (chr17) Padj(eQTL) Effect size GWAS pieQTL
SNP Disease or trait Padj(gwas)
SNP Distance(bp) from TSS Cell type Padj(eQTL)
Reference Title of article Pubmed ID

UCSC Genome Browser

RNA expression levels (in reads per million) averaged across samples are shown for each cell type, along with the Gencode annotations. Controls allow you to zoom in/out, move to a different region of the genome, change scales, or add/remove tracks. Future versions will also display SNPs/eQTLs as separate tracks.

Gene networks

Click on 'Explore gene networks' link to open up gene networks page.