Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
Common variants at 11p13 are associated with susceptibility to tuberculosis.
Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.
A genome-wide association study of pulmonary tuberculosis in Morocco.
Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration.
All SNPs associated with the selected phenotype (as defined by GWAS studies) are displayed in the table below, along with their P values and effect sizes in the DICE cohort. Clicking on a SNP name will bring you to the association plot for the given SNP, gene, and cell type.
|SNP Name||Gene||Ensembl ID||Cell Type||SNP||P Value||Effect Size||Study|
The raw P value from the eQTL analysis for a given SNP implementing the Matrix eQTL package (version 2.1.1). P values of 2 indicate low expression ( < 1 TPM ) across all cell types.
The magnitude of the change in gene expression levels associated with the genetic variant (regression slope comparing allelic effects of REF vs. ALT variant); implementing the Matrix eQTL package (version 2.1.1).